Towards a unified model of RAF inhibitor resistance.
نویسندگان
چکیده
ATP-competitive RAF inhibitors elicit profound but often temporary antitumor responses in patients with BRAF-mutant melanoma. Analysis of tumor samples collected at the time of disease progression indicates that alterations within the extracellular signal-regulated kinase (ERK) pathway that result in reactivation of ERK signaling are present in most patients. Mutations in the phosphoinositide 3-kinase/AKT pathway that enhance the adaptive response to RAF inhibitors also contribute to RAF inhibitor resistance in a subset of patients.
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عنوان ژورنال:
- Cancer discovery
دوره 4 1 شماره
صفحات -
تاریخ انتشار 2014